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The percentage of high-grade cervical lesions that progress to invasive cervical cancer has been estimated to be 50 percent or less Virtually all cervical cancers are caused by HPV infections, with just two HPV types, 16 and 18, responsible for about 70 percent of all cases.

HPV also causes anal cancer, with about 85 percent of all cases caused by HPV.

It has been estimated that, by 2020, HPV will cause more oropharyngeal cancers than cervical cancers in the United States.

Many times these infected cells are recognized by the immune system and eliminated.Sometimes, however, these infected cells are not destroyed, and a persistent infection results.As the persistently infected cells continue to grow, they may develop mutations that promote even more cell growth, leading to the formation of a high-grade lesion and, ultimately, a tumor.In the United States, more than half of the cancers diagnosed in the oropharynx are linked to HPV-16.The incidence of HPV-associated oropharyngeal cancer has increased during the past 20 years, especially among men.HPV types 16 and 18 have also been found to cause close to half of vaginal, vulvar, and penile cancers.